Background Research

Avian Influenza Vaccines

• Research identifies key point in flu transmission. Reuters, January 2008.
  
• Acambis unveils positive data for flu vaccine. Financial Times, January 2008.
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• Influenza Vaccine Causes Weaker Immune Response For Children Of Rural Gabon Than In Semi-urban Areas. ScienceDaily, October 2007.
  
• Cathel Kerr, "Effectiveness of Avian Influenza Vaccine Questioned," The Lancet Infectious Diseases 7 (June 2007): 377.
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• "Antigenic and Genetic Characteristics of H5N1 Viruses and Candidate H5N1 Vaccine Viruses Developed for Potential Use as Pre-Pandemic Vaccines," WHO Weekly Epidemiological Record 82, no. 19 (May 11, 2007): 164-67. pdf
  
• Kanta Subbarao and Catherine Luke, "H5N1 Viruses and Vaccines," PLOS Pathogens 3, no. 3 (March 2007): 1-3. pdf
  
• Otfried Kistner, M. Keith Howard, Martin Spruth, et al., "Cell Culture (Vero) Derived Whole Virus (H5N1) Vaccine Based on Wild-Type Virus Strain Induces Cross-Protective Immune Responses," Vaccine 25 (2007): 6028-36.
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• Catherine J. Luke and Kanta Subbarao, "Vaccines for Pandemic Influenza," Emerging Infectious Diseases 12, no. 1 (January 2006): 66-73. pdf
  

Research & Development

• Cross-Protection against H5N1 Influenza Virus Infection Is Afforded by Intranasal Inoculation with Seasonal Trivalent Inactivated Influenza Vaccine. November, 2007.
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• Chlorine Inactivation of Highly Pathogenic Avian Influenza Virus, Centers for Disease Control, October 2007. pdf
  
• Pandemic Influenza Preparedness: Sharing of Influenza Viruses and Access to Vaccines and other Benefits, World Health Assembly, May 2007. pdf
  
• International Federation of Pharmaceutical Manufacturers (IFPMA), R&D for Avian/Pandemic Influenza Vaccines by IFPMA Influenza Vaccine Supply International Task Force Members, January 24, 2006. pdf
  
• IFPMA, Influenza Vaccine Research & Development, October 2006. pdf
  

Stockpiling and Pre-Pandemic Vaccination

• Ben Hirschler, "European regulators OK GSK's prepandemic bird flu vaccine." Reuters, May 2008.
  
• Tan Ee Lyn, "China approves bird flu vaccine for humans." Reuters, April 2008.
  
• Steven Riley, Joseph T. Wu, and Gabriel M. Leung, "Optimizing the Dose of Pre-Pandemic Influenza Vaccines to Reduce the Infection Attack Rate," PLOS Medicine 4, no. 6 (June 2007): 1032-40. pdf
  
• Albert Osterhaus, "Editorial: Pre- or post-pandemic influenza vaccine?" Vaccine 25 (2007): 4983-4984.
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Manufacturing Capacity

• WHO flu vaccine forecast an underestimate. Article from in-Pharma Technologist.com, October 2007.
  
• Projected supply of pandemic influenza vaccine sharply increases. WHO news release, October 2007
  
• WHO Initiative for Vaccine Research (IVR), Request for Applications: Establishment of an International Technology Platform for Influenza Vaccines. pdf
  
• WHO IVR, Global Pandemic Influenza Action Plan to Increase Vaccine Supply, WHO, September 2006. pdf
  

Regulatory Issues

• WHO Meeting on Regulatory Preparedness for Human Pandemic Influenza Vaccines, June 14-15, 2007, Geneva.
  
• Center for Biologics and Evaluation Research (CBER), "Guidance for Industry Clinical Data Needed to Support the Licensure of Pandemic Influenza Vaccines," U.S. FDA, May 2007. pdf